Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments
The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM).Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and in vivo.To elucidate how leukocytes squeeze through these barriers, we co-tracked the endothelial actin fil